Biology
476 – Virology: Tentative Lecture Schedule - Spring 2008
Learning
Objectives:
1.
Understand replication cycle for positive/negative double/single
stranded
viruses
2.
Understand host responses to viral infection
3.
Understand viral strategies for replication in hosts
4.
Be able to perform experiments to characterize basic properties of
bacteriophage
Instructor:
Larry
Hanne; Holt 328; 898-6298; LHANNE@CSUCHICO.EDU
Office
hours: Tue 12 – 2; Wed 11 – 12; Thurs 12 – 2.
Required:
Carter
& Saunders. 2007. Virology: Principles and Applications
Virology
Laboratory Manual (from Omicron)
Assigned
Articles (Appendix at the back of the lab manual)
Medical
Microbiology, Baron (editor): http://gsbs.utmb.edu/microbook/toc.htm
Lecture
outlines on WebVista
Supplemental
articles (folder in Holt 329 and Electronic Library Reserve)
| Month |
Day |
Topic |
Carter & Saunders |
| Jan |
29 |
Introduction to
Virology, History, and Phages |
Ch 1, 2, 19.1 |
| 31 |
Intro (con't);
Discuss journals |
||
| Feb |
05 |
Structure and
Classification Journal: Identification of a novel coronavirus Journal: Infectivity of RNA from TMV |
Ch 3, 4 |
| 07 |
Review: Darwin's
Surprise Review: Seasonal Epidemics of Cholera |
||
| 12 |
Attachment,
Transport, and Replication |
Ch 5, 6, 7 |
|
| 14 |
Replication
(con't) |
||
| 19 |
Assembly and
Exit; Review for Exam |
Ch 8 |
|
| 21 |
Exam I (Study
questions linked here) |
||
| 26 |
Bacteriophage |
Ch 19 |
|
| 28 |
Bacteriophage
(con't) Journal: Overlapping genes in bacteriophage |
||
| Mar |
04 |
Evolution |
Ch 20 |
| 06 |
Journal:
Specific gangliosides function Journal: A sorting signal for basolateral delivery |
||
| 11 |
Transmission |
Ch 10 |
|
| 13 |
Outcomes of
viral infection |
Ch 9 |
|
| 17 |
SPRING BREAK |
||
| 25 |
Cancer; Review
for Exam Review: Mechanisms of HPV-induced oncogenesis |
Ch 22 |
|
| 27 |
Exam II (Study
questions linked here) |
||
| Apr |
01 |
Immunity Review: Innate sensing of viruses by TLR |
Wagner Ch 7 & pp 126-130 |
| 03 |
Vaccines;
Antivirals; Disinfection MMWR: 2008 Recommended Childhood Vaccines Review: RNA silencing |
Ch 23, 24, 25 |
|
| 08 |
Herpesviruses
and other dsDNA viruses Journal: Antiviral peptides targeting WNV |
Ch 11 |
|
| 10 |
Herpes (con't) |
||
| 15 |
Bioinformatics |
Wagner Ch 24 |
|
| 17 |
Parvoviruses and
other ssDNA viruses |
Ch 12 |
|
| 22 |
Positive-strand
ssRNA viruses Journal: Chemical synthesis of Poliovirus |
Ch 14 |
|
| 24 |
Negative-strand
ssRNA viruses Journal: Influenza virus genome consists of.. Journal: Influenza virus receptors in airway |
Ch 15 |
|
| 29 |
Review for exam |
||
| May |
01 |
Exam III (Study
questions linked here) |
|
| 06 |
Retroviruses Journal: RNA-dependent DNA polymerase |
Ch 16, 18 |
|
| 08 |
HIV |
Ch 17 |
|
| 13 |
Prions and
viroids Journal: Why old world monkeys resist HIV Journal: Removal of Arg 332 allows.... Review: General model of prion strains |
Ch 26 |
|
| 15 |
Future of
virology and emerging infections |
Ch 21 |
|
| 20 |
Comprehensive
Final Exam (questions linked here) Tuesday, 10:00 AM |
| Grading |
Points |
| Exam I |
60 |
| Exam II |
100 |
| Exam III |
100 |
| Comprehensive
Final Exam |
150 |
| Laboratory
Notebook |
100 |
| Journal Analyses
(7 of 8) |
70 |
| Laboratory Participation |
20 |
| Total |
600 |
Laboratory
Participation: This addresses
attendance,
punctuality, contribution to team projects, and being prepared for
discussions. If you are absent or
late often, your grade will be impacted significantly. More than 6
absences
will result in a failing grade for the course.
Drop Policy: Please note that to
drop a course after the end
of the fourth week of classes requires a "serious and compelling"
reason. Therefore, before you
request a late drop for this class, obtain written documentation of
your reason
for withdrawal. I will not
consider any late drops without verification of "serious and
compelling."