Biology 476 - Virology

Tentative Lecture Schedule - Spring 2008 

Learning Objectives:

  • Understand replication cycle for positive/negative double/single stranded viruses
  • Understand host responses to viral infection
  • Understand viral strategies for replication in hosts
  • Be able to perform experiments to characterize basic properties of bacteriophage

Instructor:

Larry Hanne; Holt 328; 898-6298; LHANNE@CSUCHICO.EDU
Office hours: Tue 12 – 2; Wed 11 – 12; Thurs 12 – 2.

Required:              

Carter & Saunders. 2007. Virology: Principles and Applications
Virology Laboratory Manual (from Omicron)

Additional Reading:                

Assigned Articles (Appendix at the back of the lab manual)
Medical Microbiology, Baron (editor): http://gsbs.utmb.edu/microbook/toc.htm
Lecture outlines on WebVista
Supplemental articles (folder in Holt 329 and Electronic Library Reserve)
Month
Day
Topic
Carter & Saunders
Jan
29
Introduction to Virology, History, and Phages
Ch 1, 2, 19.1

31
Intro (con't); Discuss journals

Feb
05
Structure and Classification
Journal: Identification of a novel coronavirus
Journal: Infectivity of RNA from TMV
Ch 3, 4

07
Review: Darwin's Surprise
Review: Seasonal Epidemics of Cholera


12
Attachment, Transport, and Replication
Ch 5, 6, 7

14
Replication (con't)


19
Assembly and Exit; Review for Exam
Ch 8

21
Exam I (Study questions linked here)


26
Bacteriophage
Ch 19

28
Bacteriophage (con't)
Journal: Overlapping genes in bacteriophage

Mar
04
Evolution
Ch 20

06
Journal: Specific gangliosides function
Journal: A sorting signal for basolateral delivery


11
Transmission
Ch 10

13
Outcomes of viral infection
Ch 9

17
SPRING BREAK


25
Cancer; Review for Exam
Review: Mechanisms of HPV-induced oncogenesis
Ch 22

27
Exam II (Study questions linked here)

Apr
01
Immunity
Review: Innate sensing of viruses by TLR
Wagner Ch 7 &
pp 126-130 

03
Vaccines; Antivirals; Disinfection
MMWR: 2008 Recommended Childhood Vaccines
Review: RNA silencing
Ch 23, 24, 25

08
Herpesviruses and other dsDNA viruses
Journal: Antiviral peptides targeting WNV
Ch 11

10
Herpes (con't)


15
Bioinformatics
Wagner Ch 24

17
Parvoviruses and other ssDNA viruses
Ch 12

22
Positive-strand ssRNA viruses
Journal: Chemical synthesis of Poliovirus
Ch 14

24
Negative-strand ssRNA viruses
Journal: Influenza virus genome consists of..
Journal: Influenza virus receptors in airway
Ch 15

29
Review for exam

May
01
Exam III (Study questions linked here)


06
Retroviruses
Journal: RNA-dependent DNA polymerase
Ch 16, 18

08
HIV
Ch 17

13
Prions and viroids
Journal: Why old world monkeys resist HIV
Journal: Removal of Arg 332 allows....
Review: General model of prion strains
Ch 26

15
Future of virology and emerging infections
Ch 21

20
Comprehensive Final Exam (questions linked here)
Tuesday, 10:00 AM

Grading
Points
Exam I
  60
Exam II
100
Exam III
100
Comprehensive Final Exam
150
Laboratory Notebook
100
Journal Analyses (7 of 8)
  70
Laboratory Participation
  20
Total
600

Laboratory Participation: This addresses attendance, punctuality, contribution to team projects, and being prepared for discussions.  If you are absent or late often, your grade will be impacted significantly. More than 6 absences will result in a failing grade for the course.

Drop Policy: Please note that to drop a course after the end of the fourth week of classes requires a "serious and compelling" reason.  Therefore, before you request a late drop for this class, obtain written documentation of your reason for withdrawal.  I will not consider any late drops without verification of "serious and compelling."