Biology 476 - Virology

Tentative Lecture Schedule - Spring 2008 

Learning Objectives:

• Understand replication cycle for positive/negative double/single stranded viruses
• Understand host responses to viral infection
• Understand viral strategies for replication in hosts
• Be able to perform experiments to characterize basic properties of bacteriophage

Instructor:

Larry Hanne; Holt 328; 898-6298; LHANNE@CSUCHICO.EDU
Office hours: Tue 12 – 2; Wed 11 – 12; Thurs 12 – 2.

Required:              

Carter & Saunders. 2007. Virology: Principles and Applications
Virology Laboratory Manual (from Omicron)

Additional Reading:                

Assigned Articles (Appendix at the back of the lab manual)
Medical Microbiology, Baron (editor): http://gsbs.utmb.edu/microbook/toc.htm
Lecture outlines on WebVista
Supplemental articles (folder in Holt 329 and Electronic Library Reserve)

Month	Day	Topic	Carter & Saunders
Jan	29	Introduction to Virology, History, and Phages	Ch 1, 2, 19.1
	31	Intro (con't); Discuss journals
Feb	05	Structure and Classification Journal: Identification of a novel coronavirus Journal: Infectivity of RNA from TMV	Ch 3, 4
	07	Review: Darwin's Surprise Review: Seasonal Epidemics of Cholera
	12	Attachment, Transport, and Replication	Ch 5, 6, 7
	14	Replication (con't)
	19	Assembly and Exit; Review for Exam	Ch 8
	21	Exam I (Study questions linked here)
	26	Bacteriophage	Ch 19
	28	Bacteriophage (con't) Journal: Overlapping genes in bacteriophage
Mar	04	Evolution	Ch 20
	06	Journal: Specific gangliosides function Journal: A sorting signal for basolateral delivery
	11	Transmission	Ch 10
	13	Outcomes of viral infection	Ch 9
	17	SPRING BREAK
	25	Cancer; Review for Exam Review: Mechanisms of HPV-induced oncogenesis	Ch 22
	27	Exam II (Study questions linked here)
Apr	01	Immunity Review: Innate sensing of viruses by TLR	Wagner Ch 7 & pp 126-130
	03	Vaccines; Antivirals; Disinfection MMWR: 2008 Recommended Childhood Vaccines Review: RNA silencing	Ch 23, 24, 25
	08	Herpesviruses and other dsDNA viruses Journal: Antiviral peptides targeting WNV	Ch 11
	10	Herpes (con't)
	15	Bioinformatics	Wagner Ch 24
	17	Parvoviruses and other ssDNA viruses	Ch 12
	22	Positive-strand ssRNA viruses Journal: Chemical synthesis of Poliovirus	Ch 14
	24	Negative-strand ssRNA viruses Journal: Influenza virus genome consists of.. Journal: Influenza virus receptors in airway	Ch 15
	29	Review for exam
May	01	Exam III (Study questions linked here)
	06	Retroviruses Journal: RNA-dependent DNA polymerase	Ch 16, 18
	08	HIV	Ch 17
	13	Prions and viroids Journal: Why old world monkeys resist HIV Journal: Removal of Arg 332 allows.... Review: General model of prion strains	Ch 26
	15	Future of virology and emerging infections	Ch 21
	20	Comprehensive Final Exam (questions linked here) Tuesday, 10:00 AM

Grading	Points
Exam I	60
Exam II	100
Exam III	100
Comprehensive Final Exam	150
Laboratory Notebook	100
Journal Analyses (7 of 8)	70
Laboratory Participation	20
Total	600

Laboratory Participation: This addresses attendance, punctuality, contribution to team projects, and being prepared for discussions.  If you are absent or late often, your grade will be impacted significantly. More than 6 absences will result in a failing grade for the course.

Drop Policy: Please note that to drop a course after the end of the fourth week of classes requires a "serious and compelling" reason.  Therefore, before you request a late drop for this class, obtain written documentation of your reason for withdrawal.  I will not consider any late drops without verification of "serious and compelling."