Publications

Recent Publications:

Keller, D.M., McWeeney, S., Arsenlis, A., Drouin, J., Wright, C.V.E., Wang, H, Wollheim, C.B.,White, P., Kaestner, K., and Goodman, R.H. (2007). Characterization of pancreatic transcription factor Pdx-1 binding sites using promoter microarray and serial analysis of chromatin occupancy. J. Biol. Chem. 282: 32084-32092.

Vo, N., Klein, M.E., Varlamova, O., Keller, D.M., Yamamoto, T., Goodman, R.H., and Impey, S. (2005). A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis. Proc. Natl. Acad. Sci. USA. 102: 16426-31.

Cha-Molstead, H., Keller, D.M., Yochum, G.S., Impey, S., and Goodman, R.H. (2004). Cell-type-specific binding of the transcription factor CREB to the cAMP-resonse element. Proc. Natl. Acad. Sci. USA. 101: 13572-13577.

Florescent Image
Mouse insulinoma MIN6 cells stained with a fluorescent insulin antibody, revealing the polarized secretory macherinery of pancreatic beta cells.

Beta Cells

Target Genes Insulin

Diagram of a feed-forward transcriptional network in pancreatic beta cells in which Pdx-1 controls the expression of the insulin gene as well as the expression of transcription factors. This type of network can promote long-term activation of the target genes.
Network Pax6
A proposed multi-component loop in which Pdx-1 activates the expression of the transcription factor Pax6, and vice versa. This type of transcriptional network stabilizes the expression of each factor.
Mir-375 Network
A diagram showing a gene regulatory network involving transcription factors and microRNA that functions to control pancreatic beta cell development and insulin release. It is unclear how Pdx-1 and NeuroD1 regulate miR-375 at this time.