Biological Sciences Seminars Available for Viewing
The Biological Sciences Seminars are now available for viewing. The presentations have been transcribed and the transcriptions with PowerPoints are available online.
Graduate Students Wanted
Donor Impact Report now available.
College of Natural Sciences Alumni Reunion:
October 11-12, 2013
Keller, D.M., McWeeney, S., Arsenlis, A., Drouin, J., Wright, C.V.E., Wang, H, Wollheim, C.B.,White, P., Kaestner, K., and Goodman, R.H. (2007). Characterization of pancreatic transcription factor Pdx-1 binding sites using promoter microarray and serial analysis of chromatin occupancy. J. Biol. Chem. 282: 32084-32092.
Vo, N., Klein, M.E., Varlamova, O., Keller, D.M., Yamamoto, T., Goodman, R.H., and Impey, S. (2005). A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis. Proc. Natl. Acad. Sci. USA. 102: 16426-31.
Cha-Molstead, H., Keller, D.M., Yochum, G.S., Impey, S., and Goodman, R.H. (2004). Cell-type-specific binding of the transcription factor CREB to the cAMP-resonse element. Proc. Natl. Acad. Sci. USA. 101: 13572-13577.
|Mouse insulinoma MIN6 cells stained with a fluorescent insulin antibody, revealing the polarized secretory macherinery of pancreatic beta cells.|
|Diagram of a feed-forward transcriptional network in pancreatic beta cells in which Pdx-1 controls the expression of the insulin gene as well as the expression of transcription factors. This type of network can promote long-term activation of the target genes.|
|A proposed multi-component loop in which Pdx-1 activates the expression of the transcription factor Pax6, and vice versa. This type of transcriptional network stabilizes the expression of each factor.|
|A diagram showing a gene regulatory network involving transcription factors and microRNA that functions to control pancreatic beta cell development and insulin release. It is unclear how Pdx-1 and NeuroD1 regulate miR-375 at this time.|