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|Mouse insulinoma MIN6 cells stained with a fluorescent insulin antibody, revealing the polarized secretory macherinery of pancreatic beta cells.|
|Diagram of a feed-forward transcriptional network in pancreatic beta cells in which Pdx-1 controls the expression of the insulin gene as well as the expression of transcription factors. This type of network can promote long-term activation of the target genes.|
|A proposed multi-component loop in which Pdx-1 activates the expression of the transcription factor Pax6, and vice versa. This type of transcriptional network stabilizes the expression of each factor.|
|A diagram showing a gene regulatory network involving transcription factors and microRNA that functions to control pancreatic beta cell development and insulin release. It is unclear how Pdx-1 and NeuroD1 regulate miR-375 at this time.|