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College of Natural Sciences Alumni Reunion:
October 11-12, 2013
John R. Mahoney
Immunology & Cell Biology
Professor, 2013
Office Hours:
Spring 2013
Mon. = noon - 1pm
Thurs. = 11am - noon
Department of Biological Sciences
California State University
Chico, California 95929-0515
Office: Holt 114
Campus phone # (530) 898-6410
Education:
- PhD, Univ. Minn. 1985
- PostDoc, Rockefeller Univ.
Research Interests:
- Host-pathogen interactions
- Inflammation
- Signal transduction
Research Summary:
An integral part of the inflammatory response is the production of reactive oxygen species including, superoxide, hydrogen peroxide, and hypochlorous acid. In addition to potent antimicrobial activity, recent work has demonstrated that these compounds elicit specific biological responses from cells. Two of my current graduate students are examining the effect at the effects of HOCl (chlorine bleach) on endothelial cell morphology and vascular physiology. Using an isolated perfused rat heart model and an aortic ring model we are investigating functional and morphological changes using light and electron microscopy. Previous, studies in my lab have demonstrated that HOCl and other neutrophil-derived oxidants may have other important functions in the inflammatory response involving changes in endothelial cell morphology and signal transduction pathways.