Zebrafish stem and progenitor cells and their dysregulation in leukemogenesis

PI’s:

David Stachura, Ph.D.

Project Title:

Zebrafish stem and progenitor cells and their dysregulation in leukemogenesis

(1 K01 DK087814-01A1).

Funding Agency:

National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases

Dates:

07/01/11-06/31/16

Award Amount:

$720,000

Project Abstract: The hematopoietic system is one of the best-studied models of developmental restriction whereby hematopoietic stem cells (HSCs) progressively lose their ability to self renew, differentiating into lineage-committed progenitor cells and eventually lineage-restricted mature blood cells.  As HSCs are responsible for supplying an organism mature, functional blood and immune cells over its entire lifespan, regulation of this commitment and differentiation is essential, with perturbations of these restrictive developmental processes resulting in serious clinical manifestations such as anemia, thrombocytopenia, and neutropenia.  This project is the first of it’s kind to identify and study the biology of these enigmatic stem and progenitor cells in the zebrafish, a genetically amenable vertebrate model system with blood development extremely similar to humans.

zebra fish