Wikipedia Grading Rubric Criteria Value Evidence 1. The student understands how alterations in this gene effect the health of afflicted individuals The phenotypic consequences of inheriting common disease alleles for this gene (symptoms, disease progression, prognosis, etc.) are included in the report. 2. The student understands the common types of gene functions at different organizational levels - type of protein (enzymes, membrane proteins, transcription factors, etc.), cellular function (biochemical pathway, secretory, signaling, etc.) tissue or organ function (muscle, neuronal, sensory, skin, etc.), and developmental or organism phenotype (polydactyly, diabetes, muscular dystrophy, etc.)   The genes normal function, if known, is clearly explained at all applicable levels 3. The student understands the common inheritance patterns and can correctly use the terms for them The report describes the inheritance pattern (autosomal dominant, x-linked recessive, autosomal lethal, multi-factorial, etc.) and the potential risk for unborn individuals in affected families 4. The student understands the terminology for the common types of mutations.   The report describes the type of mutation at the level of DNA (point mutation, deletion, inversion, etc.), protein (missense ala to lys, frameshift, regulatory, splicing, etc.) and protein function (inactivated protein, alteration in protein level, etc.) 5. The student understands basic population genetics and can use allele frequency data and the inheritance pattern of the disease allele to estimate the risks of particular couples having children with the disease The frequency of the mutant allele(s) in populations of interest is reported and there is a discussion of the risks of parents having children with the disease depending on whether family members have, or have not, been afflicted. 6. Student understands the terminology used to describe a genes location on a chromosome. The genes map location is given correctly. 7.Student understands the details of how DNA is used to produce functional RNAs and proteins The genes physical structure is described: the length of the functional DNA, the location of any known regulatory regions, the number of exons, the size of the mRNA and the protein size. 8. Student can assemble information form different sources into a coherent written report The report is neat and well organized following the format of other Wikipedia genetic disorder articles, and has been edited so that there are no typos or poorly written sentences. 9. Student shows an ability to write for disparate audiences   Appropriate terminology for a general audience is used with complex scientific and medical terminology from the sources either explained or replaced with simpler language 10. Student is able to search different genetic databases and extract the appropriate information Sources are cited and all available information is found and included in the report. This document is copyright of Jeff Bell Last Update: Monday, July 17, 2006