Chemistry and Biochemistry

Carolynn Arpin

Organic Chemistry

Education

University of Toronto, Postdoctoral Researcher
Ph.D. University of Colorado, Boulder, CO
B.Sc. Georgia Southern University, Statesboro, GA

Research Interests

My background in organic reaction development and current work in medicinal chemistry has steered my own research interests towards the development of innovative synthetic methods and their utilization in building small molecules that inhibit protein-protein interactions of therapeutic relevance. More information can be found on my website(opens in new window).

Publications

“Designed Metabolic Optimization of Potent Stat3 Protein Inhibitors as Pancreatic Cancer Therapeutics”. Arpin, C. C.; Page, B. D. G.; Haftchenary, S.; Fishel, M. L.; Gunning, P. T. Journal of Medicinal Chemistry2013, in preparation.

“Application of Small Molecule Stat3 Protein-Membrane Anchors in Human Cancers”. Arpin, C. C.; Avadisian, M. A.; Yue, P.; Gunning, P. T. Chemical Communications2013, in preparation.

“Combined STAT3 and BCR-ABL1 Inhibition Restores Response in Therapy-Resistant Chronic Myeloid Leukemia”. Eiring, A. M.; Page, B. D. G.; Kraft, I. L.; Mason, C. C.; Zhang, T. Y.; Vellore, N. A.; Khorashad, J. S.; Engar, A. J.; Reynolds, K. R.; Zabriskie, M. S.; Anderson, D. J.; Senina, A.; Pomicter, A. D.; Arpin, C. C.; Ahmad, S.; Heaton, W. L.; Tantravahi, S.; Moriggl, R.; Baron, R.; O’Hare, T.; Gunning, P.T.; Deininger, M. W. Nature Chemical Biology2013, submitted.

“BP-4-018, a Novel Small-Molecule Inhibitor of STAT3, Demonstrates Significant Anti-tumor Activity Against Multiple Myeloma”. Croucher, D.C.; Page, B. D. G.; Li, Z. H.; Aman, A.; Arpin, C. C.; Gunning, P. T.; Trudel, S. Cancer Research2013, submitted.

“Progress towards the development of SH2 domain inhibitors”. Arpin, C. C.; Kraskouskya, D.; Duodu, E.; Gunning, P. T. Chemical Society Reviews2013, 42, 3337-3370.

“The Total Synthesis of Dermostatin A”. Zhang, Y.; Arpin, C. C.; Cullen, A. J.; Mitton-Fry, M. J.; Sammakia, T. Journal of Organic Chemistry2011, 76 (19), 7641-7653.

“New Inhibitors of Colony Spreading in Bacillus subtilis and Bacillus anthracis”. Hao, X.; Nguyen, T.; Kearns, D. B.; Arpin, C. C.; Fall, R.; Sammakia, T. Bioorganic and Medicinal Chemistry Letters2011, 21 (18), 5583-5588.

Patents

“New Salicylic Acid Derivatives, Pharmaceutically Acceptable Salt Thereof, CompositionThereof and Method of Use Thereof”. Gunning, P. T.; Weiss, S.; Haftchenary, S.; Page, B.D. G.; Arpin, C. C., Cumaraswamy, A. Patent Pending.